Aging changes everything—not just the way we look, but the way our cells function. One of the biggest changes is a decline in NAD+, a vital coenzyme that fuels energy production, repair, and resilience in every cell. By the time most of us hit our 60s, NAD+ levels may have dropped by 50%.

That’s where 1-MNA (1-methyl nicotinamide) comes in.

1-MNA is a natural compound your body makes when it breaks down niacin (vitamin B3) from food sources like mushrooms, meat, peanuts, or celery. At optimal levels, it helps your body maintain NAD+, regulate energy production, and support multiple systems tied to aging and disease prevention.

Where Does 1-MNA Come From?

Your body produces 1-MNA naturally in the liver, but levels decline with age. You can also get small amounts from food, such as:

• Wakame seaweed: 3.2 mg per 100g
• Green tea leaves: 3.0 mg per 100g
• Chicken gizzards: 2.4 mg per 100g
• Celery: 1.6 mg per 100g
• Mushrooms (black Chinese): 1.3 mg per 100g
• Natto (fermented soybeans): 1.0 mg per 100g

Still, dietary intake is tiny compared to what your body needs for optimal support. Supplementation is the most effective way to restore levels.

Is 1-MNA Safe?

Yes. Studies show 1-MNA is well tolerated and safe for long-term use at therapeutic doses (around 58 mg daily). It should be avoided during pregnancy or breastfeeding due to limited research in those groups, but for most adults, it’s considered safe.