How Inflammation Really Works—and the Nutrient That Helps Calm It

Every chronic disease—from autoimmune conditions to gut problems, skin flare-ups, and chronic pain—shares one common thread: out-of-control inflammation.

At the center of this storm is something called NF-κB (nuclear factor kappa-light-chain- enhancer of activated B cells). It’s a “master switch” inside your cells that controls over 500 inflammatory genes. When NF-κB gets stuck in the “on” position, the result is a constant flood of inflammation that damages tissues and drives disease.

The Cellular Cascade of Inflammation

Here’s what happens when NF-κB goes unchecked:

• It triggers the release of pro-inflammatory cytokines like TNF-α, IL-1β, and IL-6
• It breaks down IκB proteins, which normally keep NF-κB under control
• It moves into the cell nucleus and flips on inflammatory genes
• It creates a self-sustaining cycle of inflammation that’s very hard to stop

Most traditional anti-inflammatory treatments (like pain relievers or steroids) only target the downstream effects of this process. They don’t stop the root cause—NF-κB itself.

Enter Butyrate: Nature’s Inflammation Modulator

This is where butyrate comes in. Butyrate is a short-chain fatty acid made by the “good bacteria” in your gut when they break down fiber. It acts as a natural gene expression modulator, directly calming NF-κB.

Here’s how butyrate works:

• HDAC Inhibition – Prevents NF-κB from switching on inflammatory genes
• IκB Stabilization – Keeps NF-κB “locked away” so it can’t trigger inflammation
• Direct Gene Suppression – Reduces the activation of hundreds of inflammatory genes
• Metabolic Reprogramming – Helps gut cells shift into a healthier energy mode, reducing inflammatory stress

The Clinical Impact

Studies have shown that healthy levels of butyrate can:

• Reduce intestinal permeability (“leaky gut”) by up to 73%
• Lower inflammatory markers by as much as 60%
• Improve insulin sensitivity
• Boost immune balance by supporting regulatory T cells
• Strengthen the gut barrier to protect against toxins and pathogens

Why Most Butyrate Supplements Don’t Work

Here’s the catch: most butyrate supplements fail to reach the colon, where NF-κB modulation actually happens. The problems are:

• They get absorbed too early in the digestive tract
• They lack true bioavailability
• They often smell and taste unpleasant—hurting compliance

The Tributyrin Advantage

nuButyrate™, which uses tributyrin - a form of butyrate that is proven to survive digestion and release in the colon where it’s needed most.

Benefits of tributyrin include:

• Protected delivery through the upper GI tract
• Targeted release in the colon for maximum effect
• No bad taste or smell (much easier for patients to take)
• Works synergistically with other anti-inflammatory protocols

Why Butyrate Belongs in Every Anti-Inflammatory Plan

Butyrate is known as “a vitamin for the gut”, but it’s really more than that. It’s a foundation for whole-body health because it influences:

• Gene expression and inflammation control
• Immune system balance
• Metabolic flexibility
• Gut barrier strength
• Cellular energy production

If you’re only treating inflammation downstream, you’re missing the bigger picture. To truly make progress, you have to address inflammatory gene expression at the source.

Patient-Friendly FAQ

1. What exactly is butyrate?
   Butyrate is a natural compound made when healthy gut bacteria break down dietary fiber. It’s one of the most important nutrients for gut and immune health.
   
   
2. Do I need a supplement if my body makes butyrate naturally?
   Many people don’t make enough butyrate because of poor gut bacteria balance or low fiber diets. Supplementing can help restore optimal levels.
   
   
3. How is nuButyrate™ different from other butyrate supplements?
   Most butyrate supplements get absorbed too early in the digestive tract, so they never reach the colon—where they’re needed most. nuButyrate™ uses tributyrin, which survives digestion and delivers butyrate directly to the colon.
   
   
4. Can this help if I don’t have digestive symptoms?
   Yes. Butyrate doesn’t just support digestion—it regulates inflammation throughout the body. People struggling with autoimmune issues, fatigue, skin flare-ups, or brain fog may benefit, even if their digestion feels fine.
   
   
5. Is it safe?
   Yes. Butyrate is a natural substance already found in your body. nuButyrate™ simply helps restore healthy levels in the right place for maximum benefit.

Take the Next Step Toward Healing

If you’re ready to move beyond symptom-chasing and finally address inflammation at the root, nuButyrate™ is available through Dr. Kevin Greene and Confidia Health Institute.

Dr. Greene and his team specialize in functional, root-cause medicine—focusing on the root causes of illness, not just the symptoms. We are committed to guiding every patient toward whole-body healing—starting at the cellular level.

Ask Confidia Health Institute about nuButyrate™ today and discover how targeted inflammation control can transform your health.