Zonulin/Larazotide
The Gut Barrier Breakthrough: Why Zonulin May Be the Missing Link
You’re doing everything right for gut health—using peptides, butyrate, probiotics, and more. Yet some patients still struggle with
persistent gut permeability, often called “leaky gut.”
Why? Because the real missing piece isn’t being addressed.
That piece is zonulin.
What Is Zonulin—and Why Does It Matter?
Zonulin is a protein that acts as the master regulator of the gut barrier. It controls the “tight junctions”—the tiny gates between your intestinal cells.
When zonulin levels are too high, those gates open. The result?
- Toxins and pathogens slip into the bloodstream
- Inflammation spreads throughout the body
- The gut barrier weakens by up to 70%
- Autoimmune diseases can accelerate
In fact, research shows that elevated zonulin levels can even predict when silent autoimmunity turns into active inflammatory disease.
Meet Larazotide: The Zonulin Blocker
Most gut treatments work around the problem. But Larazotide acetate - an 8-amino acid peptide - targets it directly.
Here’s how it works:
- Blocks zonulin from binding to receptors (EGFR and PAR2)
- Prevents the tight junctions from being pulled apart
- Keeps the intestinal lining sealed and protected
- Restores barrier integrity in just days
In short: Larazotide stops the leak at its source.
Who Benefits from This Protocol?
Practitioners are already using this approach with success in:
- Autoimmune conditions (like arthritis, Hashimoto’s, and celiac-related issues)
- Post-COVID complications (including Long COVID and MIS-C)
- Metabolic dysfunction (insulin resistance, chronic inflammation)
- Neurological issues (brain fog, mood changes from gut-brain disruption)
What Research Shows
Clinical studies on Larazotide demonstrate:
- A measurable reduction in gut permeability markers
- Improved gut symptom scores
- Lower inflammatory cytokine levels
- A strong safety record with minimal side effects
Patients typically notice improvement in 7–14 days, with full benefits within 4–6 weeks.
The Bottom Line
Most gut health protocols are like bailing water out of a sinking boat - you’re treating symptoms while the real leak continues.
This approach is different:
- Larazotide stops the leak
- Guttides™ repairs the damage
- nuButyrate™ builds long-term resilience
It’s not just managing gut dysfunction—it’s restoring the gut barrier that protects every system in the body.
Patient-Friendly FAQ
- What exactly is zonulin?
Zonulin is a protein that controls how tightly your intestinal cells stay sealed together. When it’s elevated, the gut lining becomes “leaky,” allowing harmful substances into the bloodstream. - What is Larazotide and how does it help?
Larazotide is a small peptide that blocks zonulin from opening those gaps. It helps restore and maintain a healthy gut barrier, even under stress. - Is Larazotide safe?
Yes. Clinical studies show it has an excellent safety profile with minimal side effects. It has been tested in conditions like celiac disease and autoimmune-related gut issues. - How soon will I feel the results?
Most patients start to notice improvements in gut symptoms, energy, or inflammation within 1–2 weeks. Full results typically build over 4–6 weeks. - Do I need to take Larazotide alone, or with other gut therapies?
Larazotide works best when combined with gut-healing strategies like Guttides™ and nuButyrate™. Together, they stop the leak, repair damage, and strengthen long-term gut health.
Take the Next Step with Confidia Health Institute
Dr. Greene and his team specialize in functional, root-cause medicine—helping patients heal from the inside out with evidence-based strategies for gut health, autoimmunity, and whole-body vitality.
If you’re ready to move beyond temporary fixes and actually repair your gut barrier, these advanced protocols are available through Dr. Kevin Greene and Confidia Health Institute.
👉 Ask Confidia Health Institute about Larazotide protocols today—and take the first step toward restoring your gut barrier and protecting your long-term health.